
The team enters the reductive electrocatalysis arena demonstrating the power of voltage control and redox mediators. In an exciting collaboration with the Gutierrez group at UCLA, Bryan and team show a highly Z-selective Co-catalyzed semi-hydrogenation that allows for the synthesis of stilbenoid natural products, such as Combretastatin A4. DFT reveals a unique stereoselectivity model based on distortion analysis of the ligand-substrate dihedral angles. We are excited to continue developing based on these insights!
For a link to the preprint, see: https://chemrxiv.org/engage/chemrxiv/article-details/67880e2481d2151a024e5262
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